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. 2018 Aug 29;374(3):607–617. doi: 10.1007/s00441-018-2905-z

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — The S117A-FGF2 protection from Dox requires ERK activity. (a) The effect of S117A-FGF2 on pERK/ERK ratio after 30 min cardiomyocyte stimulation and after Dox exposure for another 30 min. Images of the corresponding western blots probed for anti-pERK or anti-ERK are also included (a′, n = 3). (b) The effect of UO126 (inhibitor of ERK activation) on S117A-FGF2 protection from Dox-induced LDH release. Brackets point to groups that are significantly different from each other. In the presence of UO126, S117A-FGF2 is unable to reduce Dox-induced LDH release