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. 2018 Nov 27;10:6431–6444. doi: 10.2147/CMAR.S182980

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© 2018 Wang et al. This work is published and licensed by Dove Medical Press Limited

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Effects of NLRP6 on STAT3 signaling.

Notes: (A) Immunoblot of phosphorylated STAT3, STAT3, Bcl-2, and MMP-2. Blots are representative of three separate experiments. (B) mRNA levels of Bcl-2 and MMP-2 were assessed by qRT-PCR. (C) BGC-823 and HGC-27 cells were transfected with a Bcl-2 or an MMP-2 luciferase reporter plasmid. The cells were then cultured for 48 hours before determination of normalized luciferase activity. WT, wild-type cells; vector, cells stably expressed control vector; NLR6, cells stably expressed NLRP6. ^***P<0.001.

Abbreviation: qRT, quantitative reverse transcription.