Table 1.

Inclusion and exclusion criteria

Inclusion criteria	Exclusion criteria
Severe, primary, or secondary Raynaud’s phenomenon (intense and incapacitating pain)	Active infection at the injection site
Presence of ulcers and/or necrosis	Hypersensitivity to botulinum toxin or drug delivery vehicle
Distal capillary filling of >8 s	Earlier thoracic sympathectomy
Refractory reaction to conventional medical treatments (calcium antagonists)	Pregnant or breastfeeding
Absence of obstructive disease confirmed by Doppler echocardiography