Table 4.

Causes of Bone Fragility Increase in Patients With DM

Type 1 DM	Type 2 DM
Decreased BMD Cachexia Lack of insulin Lower IGF levels Local osteopenia due to neuropathy	Localized Osteopenia Related to neuropathy
Increased Fall Risk Due to complications (visual, neuropathic, etc.) Hypoglycemia Other medications	Increased Fall Risk Due to complications (visual, neuropathic, etc.) Hypoglycemia Medications
Defective of Bone Quality Increased AGEs	Defective Bone Quality Increased AGEs
	Medications of DM Tiazolidinediones

AGEs: advanced glycosylated end products; BMD: bone mineral density; DM: Diabetes Mellitus; IGF: insulin-like growth factor