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. 2018 Nov 27;10:6399–6407. doi: 10.2147/CMAR.S166711

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© 2018 Ye et al. This work is published and licensed by Dove Medical Press Limited

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Analysis and detection of PYCR1 coexpression genes in human MM.

Notes: (A–C) PYCR1 coexpression genes were identified using the GEPIA dataset. FOXK2, RPTOR and RAC3 showed a similar expression pattern to that of PYCR1 in SKCM. (D–F) siPYCR1 inhibited FOXK2 and RPTOR expression, but not RAC3 expression in A375 cells. ^*P<0.05.

Abbreviations: MM, malignant melanoma; NC, negative control; GEPIA, Gene Expression Profiling Interactive Analysis; SKCM, skin cutaneous melanoma; FOXK2, forkhead box K2; PYCR1, pyrroline-5-carboxylate reductase; RPTOR, regulatory associated protein of MTOR complex 1.