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. 2018 Nov 26;11:8201–8209. doi: 10.2147/OTT.S173008

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© 2018 Chen et al. This work is published and licensed by Dove Medical Press Limited

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Extended therapy of human LC cells with ceritinib induced CR.

Notes: (A) H1299R (generated by ceritinib supplement to H1299 cells) and (B) HCC78R (generated by ceritinib supplement to HCC78 cells), as well as corresponding parent cells, received the supplement of ceritinib for 4 days. MTT assay was used to evaluate the survival. (C) H1299R and (D) HCC78R, as well as corresponding parent cells, received the supplement of 500 nM ceritinib for 2 days. Calculation of fragmented as well as condensed nuclei was used to evaluate cell death. Data are presented as mean ± SD from three independent experiments. **P<0.01, ceritinib vs control.

Abbreviations: CR, ceritinib resistance; LC, lung cancer.