Table 2.
Univariate and multivariate Cox analyses of OS in CRC patients
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Gender (male/female) | 1.043 (0.699–1.557) | 0.873 | ||
| Age (≤60/>60) (years) | 0.600 (0.407–0.884) | 0.010 | 0.538 (0.357–0.811) | 0.003 |
| Differentiation | 0.112 | |||
| Well/poor | 0.662 (0.283–1.551) | |||
| Moderate/poor | 0.718 (0.441–1.167) | |||
| Histological subtype | 0.027 | 0.215 | ||
| Adenocarcinoma/mucinous type | 0.574 (0.351–0.938) | 0.727 (0.439–1.203) | ||
| T stage | 0.007 | 0.052 | ||
| 1–2/4 | 0.054 (0.008–0.391) | 0.085 (0.012–0.620) | ||
| 3/4 | 0.724 (0.465–1.127) | 0.937 (0.588–1.493) | ||
| N stage | <0.001 | <0.001 | ||
| 0/2 | 0.283 (0.174–0.458) | 0.319 (0.192–0.531) | ||
| 1/2 | 0.663 (0.420–1.047) | 0.563 (0.346–0.915) | ||
| Primary tumor location | 0.319 | |||
| RCC/RECC | 1.379 (0.838–2.268) | |||
| LCC/RECC | 0.891 (0.546–1.452) | |||
| Morphology | 0.292 | |||
| Infiltrative/expansive | 1.686 (0.663–4.289) | |||
| Ulcerative/expansive | 0.830 (0.490–1.408) | |||
| Tumor size (≤4/>4 cm) | 0.988 (0.649–1.504) | 0.955 | ||
| Venous invasion | 0.003 | 0.179 | ||
| Positive/negative | 2.810 (1.416–5.578) | 1.696 (0.785–3.665) | ||
| Perineural invasion | <0.001 | 0.072 | ||
| Positive/negative | 4.065 (1.946–8.491) | 2.176 (0.933–5.075) | ||
| Tumor deposit (present/absent) | 2.579 (1.296–5.133) | 0.007 | 1.580 (0.767–3.258) | 0.215 |
| Chemotherapy (yes/no) | 0.913 (0.574–1.454) | 0.702 | ||
| F-NLR | 0.001 | 0.035 | ||
| 0/2 | 0.281 (0.143–0.551) | 0.399 (0.198–0.803) | ||
| 1/2 | 0.648 (0.428–0.980) | 0.813 (0.528–1.250) | ||
Abbreviations: CRC, colorectal cancer; LCC, left colon cancer; NLR, neutrophil–lymphocyte ratio; F-NLR, combined fibrinogen and NLR; OS, overall survival; RCC, right colon cancer; RECC, rectal cancer.