Table 3.
Univariate and multivariate Cox analyses of DFS in CRC patients
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Gender (male/female) | 1.209 (0.909–1.607) | 0.192 | ||
| Age (≤60/>60) (years) | 0.930 (0.710–1.219) | 0.599 | ||
| Differentiation | 0.216 | |||
| Well/poor | 0.541 (0.286–1.023) | |||
| Moderate/poor | 0.759 (0.542–1.063) | |||
| Histological subtype | 0.338 | |||
| Adenocarcinoma/mucinous type | 0.839 (0.586–1.202) | |||
| T stage | 0.031 | 0.778 | ||
| 1–2/4 | 0.534 (0.327–0.873) | 0.878 (0.517–1.492) | ||
| 3/4 | 0.817 (0.597–1.118) | 1.067 (0.763–1.491) | ||
| N stage | <0.001 | <0.001 | ||
| 0/2 | 0.370 (0.266–0.514) | 0.453 (0.318–0.646) | ||
| 1/2 | 0.762 (0.550–1.056) | 0.674 (0.480–0.947) | ||
| Primary tumor location | 0.042 | 0.013 | ||
| RCC/RECC | 1.153 (0.813–1.637) | 1.350 (0.927–1.965) | ||
| LCC/RECC | 0.674 (0.470–0.967) | 0.686 (0.471–1.000) | ||
| Morphology | 0.002 | 0.372 | ||
| Infiltrative/expansive | 3.118 (1.614–6.025) | 1.412 (0.689–2.896) | ||
| Ulcerative/expansive | 1.196 (0.800–1.787) | 1.005 (0.657–1.535) | ||
| Tumor size (≤4/>4 cm) | 0.920 (0.692–1.223) | 0.565 | ||
| Venous invasion | 0.005 | 0.511 | ||
| Positive/negative | 2.160 (1.254–3.719) | 1.225 (0.668–2.247) | ||
| Perineural invasion | <0.001 | 0.002 | ||
| Positive/negative | 4.561 (2.784–7.473) | 2.557 (1.424–4.590) | ||
| Tumor deposit (present/absent) | 3.019 (1.920–4.747) | <0.001 | 2.194 (1.331–3.619) | 0.002 |
| Chemotherapy (yes/no) | 1.811 (1.236–2.654) | 0.002 | 1.379 (0.921–2.064) | 0.119 |
| F-NLR | <0.001 | 0.001 | ||
| 0/2 | 0.417 (0.281–0.619) | 0.474 (0.317–0.708) | ||
| 1/2 | 0.659 (0.491–0.884) | 0.684 (0.505–0.926) | ||
Abbreviations: CRC, colorectal cancer; DFS, disease-free survival; LCC, left colon cancer; NLR, neutrophil–lymphocyte ratio; F-NLR, combined fibrinogen and NLR; RCC, right colon cancer; RECC, rectal cancer.