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. Author manuscript; available in PMC: 2018 Nov 30.
Published in final edited form as: Front Biosci (Schol Ed). 2016 Jun 1;8:264–277. doi: 10.2741/s461

Figure 1.

Figure 1.

Biosynthetic pathways of anandamide. Anandamide (AEA) can be generated from N-arachidonoyl-phosphatidylethanolamine (NAPE) by 1) release of Lyso-NAPE via phospholipase A2 (PLA2) followed by cleavage by Lyso-phospholipase D (Lyso-PLD), 2) by NAPE-PLD, 3) by ABHD4-catalyzed formation of glycerophospho-AEA followed by phosphodiesterase (PDE), or 4) by release of phospho-AEA by phospholipase C followed by dephosphorylation by PTPN22. The pathway required for synthesis of AEA in the kidney is unknown.