Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Metabolic pathways of anandamide. Anandamide (AEA) can be metabolized by 1) fatty acyl amide hydrolase (FAAH) to release free arachidonic acid and ethanolamine, 2) 12- or 15-lipoxygenases to form 12(S)-hydroxyeicosatetraenoic acid-ethanolamine (HETE)-EA and 15(S)-HETE-EA and other HETEs, 3) by cytochrome P450s to form HETE-EAs and EET-EAs, and 4) by cyclooxygenase-2 (COX-2) to form prostamide E2 and other prostamides.
