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. Author manuscript; available in PMC: 2018 Nov 30.
Published in final edited form as: Hum Mutat. 2017 Jan 23;38(4):409–425. doi: 10.1002/humu.23170

Figure 2. Mutations Map to Distinct Regions of The eIF2γ Structure.

Figure 2.

A: Ribbons representation of the yeast 48S preinitiation complex (PIC; pdb 3JAP). Only the 18S rRNA of the 40S subunit (gray), Met-tRNAiMet (green), eIF2α (N-terminal domains, light yellow; C-terminal domain, yellow), eIF2β (helix α1, blue; C-terminal domain, slate) and eIF2γ (cyan) are depicted.

B: Image from panel A rotated as shown and zoomed to highlight the eIF2γ subunit. Sites of the four human mutations are highlighted: S108R (Sc D167; red), I222T (Sc V281; purple), I259M (Sc I318; blue), and I465Sfs*4 (Sc L523–C-terminus; orange).

C: Zoom of eIF2γ from panel B. The other eIF2 subunits and 48S complex components have been removed for clarity. Sites of eIF2γ mutations are colored as in panel B and labeled.