Fig. 1.

The expression levels of PTN and PTPRZ1 were increased in breast cancer tissue after chemotherapy. PTN (a) and PTPRZ1 (b) expression data in human normal breast tissue (n = 291) and breast cancer tissue (n = 1085) from breast cancer patients without chemotherapy were obtained from the GEPIA database (http://gepia.cancer-pku.cn/index.html), Student’s t-test, *p < 0.05. c The correlation analyses of PTN and PTPRZ1 expression in breast cancer specimens without chemotherapy from the GEPIA database are shown, n = 1085, p = 0.7557, Pearson’s r test. Paired expression data of PTN (d) and PTPRZ1 (e) in human breast cancer specimens before and after adjuvant chemotherapy were obtained from the GEO database (https://www.ncbi.nlm.nih.gov/geo/), n = 69, t-test, *p < 0.05, **p < 0.01. f The correlation analyses of PTN and PTPRZ1 expression in breast cancer specimens after adjuvant chemotherapy is shown, n = 69, p < 0.001, Pearson’s r test