Table 5.
In vivo PK/PD parameters of enrofloxacin in E. coli O78-infected chicks using the combined concentration of enrofloxacin and ciprofloxacin for simulation
| Parameters | Blood | Liver | Lung |
|---|---|---|---|
| Emax (Log 10 cfu/mL) | −5.8 | −4.7 | −4.4 |
| EC50 | 18.28 | 17.66 | 13.59 |
| E0 (Log 10 cfu/mL) | 1.78 | 1.68 | 2.29 |
| AUC0–24/MIC for 1 log10 cfu/mL killing | 9.74 | 14.01 | 9.49 |
| AUC0–24/MIC for 3 log10 cfu/mL killing | 21.29 | 41.68 | 27.65 |
| AUC0–24/MIC for 4 log10 cfu/mL killing | 32.13 | 60.52 | 57.24 |
| Slope (N) | 4.19 | 2.67 | 4.86 |
Emax maximum effect, EC50 concentration of a drug that gives half-maximal response, E0 concentration at baseline, AUC0–24 area under the concentration-time curve from 0 to 24 h, cfu colony forming units