Table 2.
The effects of vitamin D supplementation on endothelial activation
| Variable | Number of study | Standardized mean difference | CI 95% | Heterogeneity | ||
|---|---|---|---|---|---|---|
| I2 (%) | Q | P-value | ||||
| VWF | ||||||
| Change intervention group vs. placebo group | 7 | -0.27 | −0.46, − 0.08 | 40.5 | 10.08 | 0.12 |
| ICAM-1 | ||||||
| Intervention group (after vs. before) | 4 | −0.19 | − 0.45, 0.06 | 18.9 | 3.70 | 0.29 |
| Placebo group (after vs. before) | 4 | 3.51 | 1.28, 5.73 | 97.6 | 124.47 | < 0.001 |
| Change intervention group vs. placebo group | 5 | −1.96 | −4.02, 0.09 | 97.4 | 153.96 | < 0.001 |
| VCAM-1 | ||||||
| Intervention group (after vs. before) | 6 | −0.24 | −0.44, −0.03 | 0.0 | 1.18 | 0.94 |
| Placebo group (after vs. before) | 6 | −0.08 | − 0.49, 0.33 | 76.5 | 21.32 | 0.001 |
| Change intervention group vs. placebo group | 7 | −0.50 | −1.19, 0.19 | 91.2 | 68.54 | < 0.001 |
| E-selectin | ||||||
| Intervention group (after vs. before) | 8 | −0.25 | −0.41, − 0.08 | 0.0 | 6.15 | 0.52 |
| Placebo group (after vs. before) | 8 | −0.10 | −0.37, 0.17 | 66.0 | 20.56 | 0.004 |
| Change intervention group vs. placebo group | 10 | −0.04 | −0.36, 0.28 | 78.8 | 42.49 | < 0.001 |
| Endothelin | ||||||
| Intervention group (after vs. before) | 4 | −0.45 | − 0.66, − 0.24 | 40.1 | 5.01 | 0.17 |
| Placebo group (after vs. before) | 4 | 0.11 | −0.10, 0.31 | 0.0 | 2.98 | 0.39 |
| Change intervention group vs. placebo group | 4 | −0.49 | −1.18, 0.19 | 90.5 | 31.46 | < 0.001 |
VWF von willebrand factor, ICAM-1 intercellular adhesion molecule 1, VCAM-1 vascular cell adhesion molecule 1