Table 4.
Significant associations robust to false discovery rate correction between plasma chemical concentrations and neonatal anthropometry, NICHD Fetal Growth Studies - singletons, 2009–2013.
| EDC (ng/ml) |
Birth weight (g) | Birth length (cm) | Head circumference (cm) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| β (95% CI) |
β (95% CI) |
β (95% CI) |
|||||||||||||
| Cohort | White | Black | Hispanic | Asian | Cohort | White | Black | Hispanic | Asian | Cohort | White | Black | Hispanic | Asian | |
| PBDEs: | |||||||||||||||
| 28 | −18.99(−60.17,22.19) | −33.64(−133.3,66.01) | −9.68(−34.89,15.54) | −9.78(−41.20,21.64) | −22.90(−146.71,100.97) | −0.16(−0.38,0.06) | 0.00(−0.56,0.52) | −0.12(−0.25,0.02) | −0.22†(−0.39,−0.05) | −0.29(−0.96,0.38) | −0.13(−0.26,0.01) | −0.29(−0.61,0.04) | −0.05(−0.13,0.04) | 0.01(−0.09,0.11) | −0.19(−0.59,0.21) |
| 153 | −2.69(−30.55,25.18) | −12.80(−40.90,16.15) | −1.11(−36.59,34.37) | 15.39(−53.90,85.77) | −13.20(−86.51,60.14) | −0.18*(−0.33,−0.03) | 0.00(−0.17,0.13) | −0.37††(−0.56,−0.18) | 0.01(−0.37,0.38) | −0.32(−0.72,0.08) | −0.04(−0.13,0.05) | −0.04(−0.13,0.05) | −0.06(−0.18,0.05) | 0.01(−0.22,0.24) | −0.05(−0.29,0.18) |
| PFSAs: | |||||||||||||||
| PFOA | −5.90(−28.75,16.94) | −8.91(−45.14,27.31) | −28.30(−76.22,19.52) | 11.43(−34.99,57.85) | 2.21(−48.10,52.52) | −0.23†(−0.35,−0.10) | −0.05(−0.25,0.15) | −0.47††(−0.73,−0.21) | −0.20(−0.45,0.06) | −0.20(−0.47,0.08) | −0.04(−0.12,0.03) | −0.05(−0.17,0.07) | −0.14(−0.29,0.02) | 0.03(−0.12,0.18) | −0.01(−0.18,0.15) |
| PFOSA | −2.54(−23.81,18.74) | 21.10(−24.53,66.74) | −28.20(−68.68,12.35) | −13.78(−60.29,32.74) | 10.69(−25.83,47.21) | 0.16**(0.04, 0.27) | 0.49††(0.24,0.74) | −0.03(−0.25,0.19) | 0.20(−0.05,0.45) | −0.03(−0.23,0.16) | 0.00(−0.07,0.07) | −0.06(−0.21,0.09) | −0.04(−0.17,0.09) | −0.05(−0.20,0.10) | 0.17**(0.05, 0.29) |
NOTE: Findings restricted to significant findings robust to false discovery rate (FDR) adjustment; however, all significant findings are presented in Supplemental Table 2. Separate models were run for each chemical and racial/ethnic group adjusting maternal age, education, pre-pregnant body mass index, serum lipids (except PFASs), serum cotinine, infant sex, and a chemical-maternal race/ethnic interaction term. Head circumference models also were adjusted for mode of delivery. Chemicals were log-transformed and scaled by SD. Mode of delivery was additionally adjusted for head circumference. CI, confidence interval; PBDEs, polybrominated diphenyl ethers; PFOA, perfluorooctanoic acid; PFOSA, perfluorooctane sulfonamide.
p < 0.05.
p ≤0.01.
False discovery rate (FDR) correction p < 0.05.
FDR p ≤ 0.01