Table 4.
Selected virulence associated genes found on the FHI-NMBU-03 chromosome by nBLAST
| Gene name (FHI-NMBU-03 chromosome) | Comment | Associated pathovar | % identity | Cover. | BLAST sequence |
|---|---|---|---|---|---|
| aatB | Autotransporter adhesin and virulence factor of avian pathogenic Escherichia coli. | APEC | 98.43 | 1017 / 1017 | JX402062 |
| herA | Archaeal bi-polar DNA helicase | Unknown | 99.47 | 1686 / 1686 | NZ_NLRN01000019 |
| aslA | Arylsulfatase gene | ExPEC (Invasive K1 strains) | 98.55 | 1656 / 1656 | CU928163 |
| aufC | Fimbrial usher protein gene | UPEC | 99.50 | 2595 / 2595 | KE702411 |
| cesAB | Enteropathogenic Escherichia coli chaperone for the type-III translocator proteins | EPEC/STEC | 100.00 | 324 / 324 | FM986651 |
| cesD2 | A second chaperone for the type III secretion translocator protein EspD | EPEC/STEC | 98.28 | 407 / 408 | NC013364 |
| cesT | A bivalent enteropathogenic Escherichia coli chaperone required for translocation of both Tir and Map | EPEC/STEC | 100.00 | 471 / 471 | LT903847 |
| chuA | E.coli hemeutilization protein A gene | ExPEC | 99.65 | 1983 / 1983 | LT827011 |
| cif | Type III secreted effector | EPEC/STEC | 100.00 | 849 / 849 | AF497476 |
| csgA | Major curlin subunit | Several | 99.56 | 459 / 459 | CP023388 |
| csgB | Minor curlin subunit | Several | 99.56 | 456 / 456 | CP027060 |
| csgE | Curli production assembly/transport component | Several | 98.70 | 386 / 390 | NC_011750 |
| csgF | Curli production assembly/transport component | Several | 98.08 | 417 / 417 | NC_011750 |
| csgG | Curli production assembly/transport component | Several | 97.72 | 834 / 834 | CP003034 |
| cvaA | Colicin V secretion protein gene | Several | 100.00 | 1242 / 1242 | GG773553 |
| Death on curing RelE/ParE family toxin gene | Component of Toxin-antitoxin (TA) system | Several | 100.00 | 272 / 276 | CP023388 |
| eae (subtype Beta2) | Intimin - Necessary for the production of attaching and effacing lesions on tissue culture cells | EPEC/STEC | 100.00 | 2820 / 2820 | AB647493 |
| ecpA | Common pilus major fimbrillin subunit | Several | 98.47 | 588 / 588 | BA000007 |
| ecpD | Fimbria adhesin of the E.coli common pilus | Several | 99.64 | 1644 / 1644 | CP019777 |
| elfC | Putative fimbrial usher protein | Several | 99.73 | 2595 / 2595 | CP021288 |
| entA | Enterobactin biosynthesis gene | Several | 96.12 | 747 / 747 | CP027060 |
| entE | Enterobactin biosynthesis gene | Several | 95.65 | 1611 / 1611 | CP027060 |
| entH | Enterobactin biosynthesis gene | Several | 94.93 | 414 / 414 | CP027060 |
| escC | Outer membrane secretin | EPEC/STEC | 91.68 | 1539 / 1539 | AP010958 |
| escD | Type III secretion system inner membrane ring protein | EPEC/STEC | 99.10 | 1221 / 1221 | BA000007 |
| escF | Type III secretion system needle major subunit | EPEC/STEC | 100.00 | 222 / 222 | NC_002695 |
| escJ | Required for the formation of the type III Secretion Apparatus | EPEC/STEC | 91.62 | 573 / 573 | AP010958 |
| escN | Type III secretion ATPase | EPEC/STEC | 100.00 | 1341 / 1341 | BA000007 |
| escR | Type III secretion system export apparatus protein gene | EPEC/STEC | 99.69 | 654 / 654 | BA000007 |
| escS | Type III secretion system export apparatus protein gene | EPEC/STEC | 100.00 | 270 / 270 | BA000007 |
| escT | Type III secretion system export apparatus protein gene | EPEC/STEC | 99.61 | 777 / 777 | BA000007 |
| escU | Type III secretion system LEE export apparatus switch protein gene | EPEC/STEC | 96.15 | 1038 / 1038 | AP010958 |
| escV | Translocase of the type III secretion system | EPEC/STEC | 99.70 | 2028 / 2028 | BA000007 |
| espA | Type III secretions system gene | EPEC/STEC | 100.00 | 573 / 573 | AJ225016 |
| espG | Type III secretion system effector, which localize to the Golgi apparatus and disrupt its architecture | EPEC/STEC | 98.41 | 1197 / 1197 | BA000007 |
| etgA | Lytic transglycosylase | EPEC/STEC | 100.00 | 459 / 459 | FM986650 |
| fdeC | Mediates E. coli adhesion to mammalian cells and extracellular matrix | ExPEC/STEC | 97.86 | 4251 / 4251 | CP019777 |
| sfaH | S-fimbrial protein subunit gene | ExPEC | 98.56 | 903 / 903 | KT444704 |
| flgD | Flagellar basal body rod modification protein gene | Several | 96.55 | 696 / 696 | CP027060 |
| flgM | Negative regulator of flagellin synthesis | Several | 98.97 | 290 / 294 | CP028192 |
| fmlA | Major F9-fimbrial subunit | ExPEC/IPEC | 96.81 | 564 / 564 | BA000007 |
| fyuA | Ferric yersiniabactin uptake receptor | ExPEC | 99.51 | 2022 / 2022 | CP016828 |
| gad (1) | Glutamate decarboxylase gene | Several | 99.64 | 1401 / 1401 | CP001671 |
| gad (2) | Glutamate decarboxylase gene | Several | 99.79 | 1401 / 1401 | FM180568 |
| grlA | Global regulator of LEE activator | EPEC/STEC | 97.56 | 409 / 414 | AP010958 |
| gtrA | Type IV O-antigen modification gene (Shigella flexneri) | Unknown | 90.08 | 363 / 363 | AF288197 |
| hbp | Hemoglobin-binding protease hbp autotransporter gene | ExPEC | 99.95 | 4131 / 4131 | CP009072 |
| hlyIII | Gene encoding inner membrane protein, hemolysin III family | ExPEC/IPEC | 98.41 | 690 / 690 | CP003034 |
| ibeA | Invasion protein gene | NMEC/APEC/AIEC | 98.61 | 1371 / 1371 | CP001855 |
| ibeB | Invasion protein gene | Several | 98.55 | 1383 / 1383 | AF094824 |
| ibeC/yijP/cptA | Invasion protein gene | Several | 99.77 | 1734 / 1734 | CP019777 |
| irp1 | HMWP1 nonribosomal peptide/polyketide synthase | ExPEC | 99.65 | 9492 / 9492 | CU928163 |
| irp2 | HMWP2 Yersiniabactin biosynthetic protein | ExPEC | 98.85 | 6106 / 6108 | CP006834 |
| ler | Negative autoregulator of the LEE1 operon | EPEC/STEC | 99.49 | 390 / 390 | BA000007 |
| malX | Escherichia coli pathogenicity island-marker | ExPEC | 98.61 | 1581 / 1581 | AF003742 |
| MAP | LEE effector protein gene | EPEC/STEC | 97.06 | 612 / 612 | LC053401 |
| MBL-fold metallo hydrolase gene | Putative phylogroup B2 specific marker | ExPEC | 99.52 | 1044 / 1044 | CP023388 |
| mdtH | Multidrug resistance protein gene | Several | 99.83 | 1209 / 1209 | CP019777 |
| mpc | Type III secretion system regulator gene | EPEC/STEC | 92.09 | 354 / 354 | AP010953 |
| mviM | Putative virulence factor | Several | 98.70 | 924 / 924 | CU928164 |
| nleA a | Non-LEE encoded effector A | EPEC/STEC | 99.84 | 1239 / 1239 | AB303062 |
| nleB | Non-LEE encoded effector B | EPEC/STEC | 100.00 | 981 / 981 | AB303062 |
| nleC-like gene | T3SS secreted effector NleC-like protein gene | EPEC/STEC | 100.00 | 264 / 264 | CYEL01000033 |
| nleG | Non-LEE encoded effector G | EPEC/STEC | 100.00 | 576 / 576 | AB303062 |
| nleH | Non-LEE encoded effector H | EPEC/STEC | 99.75 | 812 / 812 | AP010958 |
| usp/putative colicin | Uropathogenic specific protein gene | UPEC | 97.14 | 1782 / 1782 | CU651637 |
| sepL | Secretion switching protein gene | EPEC/STEC | 94.93 | 1046 / 1056 | BA000007 |
| sepQ | T3SS structure protein | EPEC/STEC | 95.53 | 918 / 918 | CP003109 |
| sinH | Intimin-like inverse autotransporter | ExPEC | 100.00 | 2178 / 2178 | NZ_NMHI01000013 |
| stcD | Putative fimbrial-like adhesin protein gene | IPEC | 99.71 | 1035 / 1035 | NC_018658 |
| stfD | Fimbrial protein gene | Unknown | 100.00 | 753 / 753 | LOFW01000008 |
| tir | Translocated intimin receptor protein gene | EPEC/STEC | 99.88 | 1650 / 1650 | DQ206455 |
| xhlA | Xenorhabdus nematophila haemolysin | Unknown | 99.73 | 372 / 372 | LDCR01000046 |
| ybtA | Yersiniabactin transcriptional regulator | ExPEC | 99.79 | 960 / 960 | CP028714 |
| ydeR | Fimbrial-like protein gene | Several | 98.41 | 504 / 504 | CU928163 |
| yfcV | Major subunit of a putative chaperone-usher fimbria | ExPEC | 97.18 | 567 / 567 | NC_011750 |
aFrameshifted