Fig. 9.

Schematic diagrams for the mechanism of the cardiac-specific miR-1 overexpression-induced decline in synaptic vesicle exocytosis. Overexpressed miR-1 in the hearts of Tg and MI mice were secreted into the extracellular space carried by exosomes. Exosomes entered the blood and were transported into the brain through blood circulation. After exosomes enter the brain, they were accepted by neurons and inhibited the expression of SNAP-25 by binding with the target in the 3’UTR of the Snap25 gene. The inhibition of SNAP-25 results in the impairment of vesicle exocytosis through impeding SNARE-complex formation