Table 3.
Meta analysis of miR-20a as an independent prognostic indicator for patients of various caricinomas
| No. of studies | No. of patients | Pooled HR(95%CI) | Meta regression | Heterogeneity | |||
|---|---|---|---|---|---|---|---|
| Fixed | Random | p-value | I2 | p-value | |||
| Overall | 7 | 1252 | 1.52(1.24,1.85) | 1.07(0.47,2.44) | 93.40% | 0.000 | |
| Population | 0.020 | ||||||
| Chinese | 6 | 1163 | 1.59(1.29,1.94) | 1.24(0.52,2.96) | 94.10% | 0.000 | |
| Italian | 1 | 89 | 0.37(0.11,1.17) | 0.37(0.11,1.17) | – | – | |
| Sample Size | 0.011 | ||||||
| ≥ 150 | 3 | 892 | 2.16(1.62,2.88) | 1.82(0.38,8.67) | 95.90% | 0.000 | |
| < 150 | 4 | 360 | 1.09(0.82,1.44) | 0.70(0.25,1.96) | 90.00% | 0.000 | |
| NOS Scores | 0.107 | ||||||
| ≥ 8 | 4 | 894 | 2.19(1.74,2.77) | 2.03(0.89,4.63) | 90.20% | 0.000 | |
| < 8 | 3 | 358 | 0.52(0.35,0.77) | 0.48(0.13,1.76) | 90.80% | 0.000 | |
| Specimen | 0.040 | ||||||
| Blood | 3 | 367 | 1.87(1.47,2.37) | 1.86(1.45,2.40) | 9.60% | 0.331 | |
| Tissues | 4 | 885 | 0.93(0.64,1.34) | 0.67(0.10,4.60) | 96.20% | 0.000 | |
| Tumor Category | 0.012 | ||||||
| Gastrointestinal cancer | 2 | 609 | 2.41(1.77,3.28) | 3.53(0.70,17.81) | 95.20% | 0.000 | |
| Non-gastrointestinal cancer | 5 | 643 | 1.09(0.84,1.42) | 0.64(0.47,2.44) | 92.70% | 0.000 | |
Abbreviations: 95%CI 95% confidence interval, Fixed Fixed effects model, HR Hazard ratio, NOS Newcastle-Ottawa scale scores, Random Random pooling model