Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Nov 29;18:1193. doi: 10.1186/s12885-018-5122-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 2 — Metabolic description of the tumors using [¹⁸F]FDG and Na[¹⁸F]F. Representative PET studies obtained in orthotopic models of osteosarcoma. A and B images correspond to the same animal injected with 531MII cell line, whereas C and D images were obtained from other animal injected with 143B line. The use of [¹⁸F]FDG (a, c) or Na[¹⁸F]F (b, c) allowed detection of different metabolic patterns in the tumors. Images from sections stained with hematoxylin-eosin from each tumor (e, f, g) confirmed that the 531MII cell line created heterogeneous tumors with osteoblastic or osteolytic phenotypes, whereas the 143B model generated osteolytic tumors with high cellularity. Red arrows: tumors detected by PET; asterisk: physiological utptake of Na[¹⁸F]F in knees; b: bladder showing physiological excretion of radiotracer