Table 1. Methacholine-induced airway constriction in the control group and in PCLS pre-treated with IL-13 (8 nM) for 0.5 h, 3 h and 6 h.

		Time of incubation with 8 nM IL-13
	Control	0.5 h	3 h	6 h
Mouse
EC50 [nM] Cmax [%]	87 59 ± 3	83 73 ± 8	79 78 ± 4	64 86 ± 4**
Rat
EC50 [nM] Cmax [%]	197 49 ± 4	212 84 ± 4	142 95 ± 3**	220 69 ± 4
Marmoset
EC50 [nM] Cmax [%]	53 63 ± 3	137 66 ± 3	167 55 ± 3	153 53 ± 6
Human
EC50 [nM] Cmax [%]	812 65 ± 4	380 52 ± 4	4055 58 ± 5	1567 69 ± 4

Half-maximal effective concentrations (EC₅₀) and maximal airway constriction (C_max) were calculated for every species and every time point.

**p≤0.01 (one-way ANOVA Dunnett’s multiple comparison test vs. control group).