Fig 4. PSEx-induced cytokine production by naïve cells from CD5^-/- and CD6^-/- mice.

(A) Peritoneal cells from naïve CD5^-/- (n = 3, pooled) and wild-type (n = 3, pooled) control mice, were cultured for 72 h in the presence of increasing amounts of PSEx, and then cytokine production in supernatants was analyzed by capture ELISA. Results are displayed as fold increases respect to unstimulated cells (mean +/- SEM). (B) Same as in (A) for CD6^-/- and wild-type control mice. Both experiments were performed in quadruplicates. (*) Significant differences (Student’s t-test, P <0.05) respect to unstimulated cells.