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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: Adv Colloid Interface Sci. 2018 Oct 24;262:39–49. doi: 10.1016/j.cis.2018.10.004

Table 1.

Currently FDA-approved and commercially available UCAs.

UCA Gas Shell Size (Diameter) Concentration
Optison™
(GE Healthcare) 		C3F8 Protein
Human serum albumin
𝜓₀ = −9.5 mV 		3.0 – 4.5 μm (max 32 μm)
95% less than 10 μm		 5.0–8.0 × 108 /mL
Definity®
(Lantheus) 		C3F8 Phospholipid
DPPC: 0.401 mg/ML
DPPA: 0.045 mg/mL
DPPE-mPEG5000 : 0.304 mg/mL
𝜓₀= −4.2 mV 		1.1 – 3.3 μm
(max 20 μm)
98% less than 10 μm		 1.2 × 1010 /mL
Sonovue® aka Lumas on® (Bracco) SF6 Phospholipid
DSPC: 0.038 mg/mL
DPPG: 0.038 mg/mL
PA: 0.008 mg/mL
𝜓₀= −28.3 mV 		1.5 – 2.5 μm (max 20 μm)
99% less than 10 μm		 1.5–5.6 × 108 /mL

DPPC = 1,2-dipalmitoyl-sn-glycero-3-phosphocholine; DPPA = 1,2-dipalmitoyl-sn-glycero-3-phosphate; DSPC = 1,2-distearoyl-sn-glycero-3-phosphocholine; DPPE-mPEG5000 = 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-5000]; DPPG = 1,2-dipalmitoyl-sn-glycero-3-phospho-(1’-rac-glycerol); PA = palmitic acid; 𝜓₀ is the zeta potential measured [40].