Table 2.
The MIC values of compound 3m against two resistant M. tuberculosis strains isolated from clinical cases a.
| Compd. | MIC b (μg/mL) | |
|---|---|---|
| Isoniazide-resistant TB 242 | Rifampicin-resistant TB 261 | |
| 3m | 32 | 4 |
| I | 16 | 4 |
| Isoniazide | 0.5 | 0.125 |
| Rifampicin | ≤0.25 | >32 |
a Clinical isolated single-drug resistant M. tuberculosis H37Rv were provided by Shanghai Pulmonary Hospital; b MIC = minimal drug concentration of the well in which bacterial growth is similar to that with only 10 CFU of bacteria inoculated. Identical values were obtained for each compound in three replicates by visual investigation as stated in the Experimental.