Table 3.
The IC50 values of some 2-(3-fluoro-4-nitrophenoxy)-N-phenylacetamide derivativeson six tumor cell lines.
| Compd. | IC50 a (μmol/L) | ||||||
|---|---|---|---|---|---|---|---|
| A375 b | A549 c | HepG2 d | HCT116 e | SKOV-3 f | Hela g | Vero h | |
| 3a | >40.00 | >40.00 | >40.00 | >40.00 | >40.00 | >40.00 | >40.00 |
| 3d | >40.00 | >40.00 | >40.00 | >40.00 | >40.00 | 33.19 ± 2.5 | >40.00 |
| 3g | 22.61 ± 0.9 | 38.19 ± 1.5 | 21.64 ± 1.1 | 33.84 ± 2.0 | 12.18 ± 1.3 | 20.02 ± 1.1 | >40.00 |
| 3h | >40.00 | >40.00 | >40.00 | >40.00 | >40.00 | >40.00 | >40.00 |
| 3m | >40.00 | >40.00 | >40.00 | >40.00 | >40.00 | >40.00 | >40.00 |
| 3o | 28.29 ± 1.2 | >40.00 | >40.00 | >40.00 | 28.60 ± 2.3 | 33.79 ± 1.7 | >40.00 |
a IC50 denotes half maximal inhibitory concentration. Values are means ± SEM of three independent experiments; b human melanoma cells; c lung adenocarcinoma epithelial cells; d hepatocellular liver carcinoma cells; e colorectal carcinoma cells; f ovarian carcinoma cells; g Henrietta Lacks strain cancer cells; h normal African green monkey kidney epithelial cells.