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Incidence of QT prolongation with TKIs.
| TKI Agent | Average QT prolongation (ms) | Increase in QTc >60ms (%) | QTc >500ms (%) | Torsades de pointes (%) |
|---|---|---|---|---|
| Axitinib | <10 | N/a | N/a | N/a |
| Cabozantinib | 10-15 | N/a | N/a | N/a |
| Pazopanib | N/a | N/a | 2 | <0.3 |
| Sorafenib | 8-13 | N/a | N/a | N/a |
| Sunitinib | 9.6-15.4 | 1-4 | 0.5 | <0.1 |
| Vandetanib | 36 | 12-15 | 4.3-8 | Described, % N/a |
