Skip to main content
. 2012 Nov 1;17(11):12821–12835. doi: 10.3390/molecules171112821

Table 2.

Kabachnik–Fields reactions carried out without the use of a solvent and a catalyst under MW irradiation [25].

Entry R1 R2 R3 Y Product T (°C) Yield (%) Yield (%) of catalytic methods [ref.]
1 Ph H H EtO 8a 80 a 91
100 b
2 Ph H H MeO 8b 80 a 80
80 b
3 Ph H H Ph 8c 80 94
4 Bn H H EtO 8d 100 81
5 Bn H H Ph 8e 80 88
6 Ph H Ph EtO 8f 100 93 98 [27], 85 [28], ~95 [29], 88 [30], 79 [31], 93 [32], 92 [33], ~90 [34], 96 [35], 60 [36], 86 [37], 92 [38]
7 Ph H Ph MeO 8g 100 86 98 [24], 98 [27], 92 [33]
8 Ph H Ph Ph 8h 80 87
9 Bn H Ph EtO 8i 100 83 99 [28], 84 [29], 92 [30], 85 [31], 91 [32], 91 [33], 92 [35], 92 [36], 93 [38]
10 Bn H Ph MeO 8j 100 87 95 [27], 82 [33]
11 Ph Me Ph EtO 8k 120 80 75 [27], 74 [30], 63 [35], 18 [36]
12 Bn Me Ph EtO 8l 120 84 92 [26], 80 [27], 81 [38]
13 Bn Me Ph Ph 8m 100 a 80
120 b 80
14 Ph graphic file with name molecules-17-12821-i001.jpg EtO 8n 120 81 92 [27], ~72 [29], 86 [30], 47 [31], 87 [37]
15 Bn graphic file with name molecules-17-12821-i001.jpg EtO 8o 120 91 85 [26], 90 [27], 83 [31], 80 [33], 85 [38]
16 Bn graphic file with name molecules-17-12821-i001.jpg MeO 8p 120 85 92 [27]
17 Bn graphic file with name molecules-17-12821-i001.jpg Ph 8q 100 a 80
120 b

for details see Table 3; a condensation of the oxo-component and the amine; b addition of the >P(O)H species to the Schiff-base.