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. Author manuscript; available in PMC: 2019 Oct 24.
Published in final edited form as: Neuron. 2018 Oct 24;100(2):375–388. doi: 10.1016/j.neuron.2018.09.022

Figure 3. Aging diminishes meningeal lymphatic drainage and paravascular recirculation of CSF.

Figure 3.

macromolecules Functional meningeal lymphatic vessels drain macromolecules (such as Aβ) from the CSF of the young and healthy brain. Influx of CSF through the paravascular (glymphatic) route leads to brain perfusion by CSF/ISF and paravascular efflux of macromolecules from the parenchymal ISF back into the CSF. Dysfunction of meningeal lymphatic vessels with aging contributes to impairment of influx/efflux mechanisms and to poor recirculation of CSF content.