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a) The mechanism of activation involves reorganisation of TM5 and TM6 residues Y6.48 and Y5.58. b) and_A dose-response curves involving the RxKAFSTCxSHTM6 motif residues. Normalized responses are shown as means with s.e.m. (n= 3). Comparison between the open (cyan) and closed (transparent) conformations of OR7D4.
