Skip to main content
. 2012 Jul 4;17(7):8037–8055. doi: 10.3390/molecules17078037

Figure 5.

Figure 5

Effects of ginger extracts on the phosphorylations of upstream targets in HepG2 cells. (A) Effect of ginger extracts on phosphorylation of MAPKs and Akt. HepG2 cells were treated with 50 µg/mL ginger extracts for 1 h; (B) Influence of MAPK inhibitors on GEE8080-induced Nrf2 and HO-1 expression. HepG2 cells pretreated with vehicle or 50 μM U0126 (MEK1/2 inhibitor), SP600125 (JNK inhibitor), SB202190 (p38 inhibitor), and LY294002 (Akt inhibitor) for 1 h prior to treatment with 50 μg/mL GEE8080 for 1 h. The blots are shown representative of three independent experiments with similar results and data represent the means ± S.D. Locations for each concentration marked letters are significantly different at * p < 0.05 vs. control.