Table 1.

Thermodynamic parameters and K_sv values for the drugs when bound to hTf in binary and ternary systems at various temperatures (pH 7.4).

System	T/K	KSV1/M−1	KSV2/M−1	ΔG°/kJ mol−1	ΔH°/kJ mol−1	ΔS°/J mol−1	R
		λ ex = 280 nm	λ ex = 280 nm
hTf-ROP	298	(1.16 ± 0.02) × 107	(5.29 ± 0.02) × 106	−36.93 ± 0.32			0.9982
	308	(1.03 ± 0.02) × 107	(5.05 ± 0.02) × 106	−35.71 ± 0.26	−79.17 ± 0.29	−145.25 ± 0.31	0.9983
	318	(9.83 ± 0.02) × 106	(4.92 ± 0.02) × 105	−35.01 ± 0.29			0.9981
(hTf-ASA)ROP	298	(2.34 ± 0.03) × 105	------	−36.17 ± 0.21			0.9976
	308	(2.13 ± 0.03) × 105	------	−35.83 ± 0.31	−71.54 ± 0.32	−120.22 ± 0.29	0.9983
	318	(2.02 ± 0.03) × 105	------	−35.14 ± 0.27			0.9981
hTf-ASA	298	(2.94 ± 0.02) × 104	------	−37.14 ± 0.27			0.9978
	308	(2.47 ± 0.02) × 104	------	−36.21 ± 0.27	−69.32 ± 0.14	−110.36 ± 0.31	0.9980
	318	(2.15 ± 0.02) × 104	------	−35.41 ± 0.31			0.9977
(hTf-ROP)ASA	298	(3.35 ± 0.03) × 104	------	−36.81 ± 0.33			0.9985
	308	(3.02 ± 0.03) × 104	------	−36.04 ± 0.27	−81.21 ± 0.30	−151.76 ± 0.28	0.9991
	318	(2.77 ± 0.03) × 104	------	−31.11 ± 0.30			0.9983