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. 2012 Oct 22;17(10):12449–12459. doi: 10.3390/molecules171012449

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© 2012 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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(a) Macroscopic appearance of the gastric mucosa in a rat pre-treated with 10 ml/kg of 10% Tween-20 (ulcer control). Severe hemorrhagic mucosal lesions are seen in the gastric mucosa. (b) Macroscopic appearance of the gastric mucosa in a rat pre-treated with Cimetidine (50 mg/kg). Injuries to the gastric mucosa are milder compared to the injuries seen in the ulcer control rat. (c) Macroscopic appearance of the gastric mucosa in a rat pre-treated with TNS (60 mg/kg). No injuries to the gastric mucosa are seen, and showed flattening of gastric mucosa.