Table 1.
Effect of TNS and its nickel (II) complex on ulcer area, mucus weight, pH and inhibition percentage in rats.
| Compound | Total ulcer area (mm2) | Mucus weight (g) | pH | % Inhibition |
|---|---|---|---|---|
| (Mean ± S.E.M) | ||||
| Tween-20 | 1438 ± 58 a | 0.58 ± 0.05 | 2.00 ± 0.01 | - |
| (ulcer control) | ||||
| Cimetidine | 168 ± 5 b | 0.61 ± 0.05 | 3.00 ± 0.01 | 88 |
| (+ve control) | ||||
| TNS (HD) | 3.6 ± 0.2 c | 1.33 ± 0.05 | 4.22 ± 0.01 | 100 |
| TNS (LD) | 3.6 ± 0.2 c | 1.60 ± 0.05 | 4.11 ± 0.01 | 100 |
| (TNS)2Ni (HD) | 7.2 ± 0.3 d | 1.65 ± 0.05 | 3.68 ± 0.01 | 96 |
| (TNS)2Ni (LD) | 26.4 ± 0.2 d | 2.00 ± 0.05 | 3.05 ± 0.01 | 95 |
All values are expressed as mean ± standard error mean. Means with different superscripts are significantly different. The mean difference is significant at the p < 0.05 level. HD: High dose: 60 mg/kg, LD: Low dose: 30 mg/kg.