. 2012 Dec 3;17(12):14288–14297. doi: 10.3390/molecules171214288

Table 2.

Hydrolysis of the nitrile 12b.

graphic file with name molecules-17-14288-i002.jpg

Entry	Catalyst	Reaction conditions	Yield (%) *
Entry	Catalyst	Reaction conditions	10b	15b	14b
1	NaOH ^a	CH₃OH/H₂O, Reflux, 30 h	trace	-	-
2	NaOH ^a	H₂O, Reflux, 30 h	trace	-	-
3	HCl ^b	1,4-Dioxane, Reflux, 16 h	-	20	66
4	H₂SO₄ ^c	H₂O, 100 °C, 16 h	-	23	72
5	H₂O₂ ^d/NaOH ^a	H₂O, 80 h, 20 h	7	-	-

Catalyst concentration: ^a 2 M; ^b 37%; ^c 40%; ^d 30%. * Isolated yield.