Table 1.
Summary of the cytotoxic effect of α-mangostin, BA, and cisplatin and their combinations on HCT 116 cells. The table presents the percentage inhibition of individual treatments and their combinations, and the fold change in the cytotoxicity of combinations compared to their additive cytotoxicity. The results are displayed as average ± SD (n = 3).
| 1-α-Mangostin (2.5 µg/mL) and betulinic acid (BA) | |||||
|
BA (µg/mL) |
BA (% inhibition) |
α-Man. (% inhibition) |
Combination (% inhibition) |
Additive (% inhibition) |
Fold change in BA cytotoxicity |
| 2.5 | 4 ± 0.2 | 2.0 ± 1.7 | 51 ± 2.5 | 6.5 ± 1.1 | 7.9 ± 0.9 |
| 5.0 | 9 ± 1.0 | 91 ± 1.6 | 11.6 ± 1.5 | 7.9 ± 0.8 | |
| 7.5 | 20 ± 1.5 | 99 ± 0.6 | 22.3 ± 1.8 | 4.5 ± 0.4 | |
| 10.0 | 50 ± 2.0 | 100 ± 0.1 | 51.4 ± 2.1 | 1.9 ± 0.1 | |
| 2-α-Mangostin (2.5 µg/mL) and cisplatin (Cis.) | |||||
|
Cis. (µg/mL) |
Cis. (% inhibition) |
α-Man. (% inhibition) |
Combination (%inhibition) |
Additive
(% inhibition) |
Fold change in Cis. cytotoxicity |
| 2.5 | 16 ± 2.3 | 2 ± 1.7 | 18 ± 3.3 | 18.8 ± 2.2 | 1.0 ± 0.09 |
| 5.0 | 36 ± 1.5 | 12 ± 3.6 | 37.9 ±1.7 | 0.3 ± 0.08 | |
| 7.5 | 83 ± 1.0 | 9 ± 0.3 | 83.5 ±1.0 | 0.1 ± 0.01 | |
| 10.0 | 97 ± 1.0 | 19 ± 4.5 | 97.1 ±1.0 | 0.2 ± 0.04 | |
| 3-BA (2.5 µg/mL) and Cisplatin. | |||||
|
Cis. (µg/mL) |
Cis. (% inhibition) |
BA (% inhibition) |
Combination (% inhibition) |
Additive
(% inhibition) |
Fold change in Cis. cytotoxicity |
| 2.5 | 16 ± 2.3 | 4.0 ± 0.2 | 18 ± 1.2 | 19.7 ± 1.9 | 0.9 ± 0.03 |
| 5.0 | 36 ± 1.5 | 28 ± 0.5 | 38.6 ± 1.6 | 0.7 ± 0.02 | |
| 7.5 | 83 ± 1.0 | 49 ± 1.8 | 83.7 ±1.0 | 0.6 ± 0.01 | |
| 10.0 | 97 ± 1.0 | 72 ± 1.2 | 97.1 ±1.0 | 0.7 ± 0.01 | |