Table 4.
Antimycobacterial activity of some compounds from F. vulgare.
| M. tuberculosis MIC (µg/mL) | ||||
|---|---|---|---|---|
| Fraction/Chemical compound | H37 Rv | M-10 | M-15 | M-26 |
| Fraction 7 | ||||
| α-Thujone | >200 | ND | ND | ND |
| Anethole | >200 | ND | ND | ND |
| Eugenol | 100 | ND | ND | ND |
| Oleic acid | 100 | 100 | 100 | 100 |
| Linoleic Acid | 100 | 100 | 100 | 100 |
| 2-Hydroxy-1-methyl-1-cyclopenten-3-one | >200 | ND | ND | ND |
| 1,3-Benzenediol a | 200 | 200 | 100 | 100 |
| Fraction 8 | ||||
| Terpinolene | 200 | ND | ND | ND |
| o-Cymene | 50–100 | ND | ND | ND |
| 3-Methyl-2-cyclopenten-1-one | >200 | ND | ND | ND |
| Isocitronellol | >200 | ND | ND | ND |
| Fraction 9 | ||||
| Fenchylacetate | >200 | ND | ND | ND |
| Carvone | >200 | ND | ND | ND |
| p-Anisaldehyde | 100 | ND | ND | ND |
| Fenchone | 200 | ND | ND | ND |
| Methylchavicol | >200 | ND | ND | ND |
| Estragole | 100–200 | ND | ND | ND |
| Undecanal | 100 | 200 | 100 | 50 |
| 2,4-Undecadienal | 25 | 50 | 25 | 25 |
| 2,3-Dimethyl-2,3-butanediol | >200 | ND | ND | ND |
| Ethambutol | 2.0 | 15 | 15 | 15 |
H37Rv: Sensitive to izoniazid, rifampicin, ethambutol and pyrizanamide. M10, M15, M26: multidrug-resistant. ND: not determined; a 1,3-Benzenediol was found in fractions 7, 8 and 9.