Table 2.
Anti-inflammatory activity of kramecyne on carrageenan-induced edema.
| Time h | Indomethacin | (% inhibition) | ||||
|---|---|---|---|---|---|---|
| Kramecyne | ||||||
| 8 mg/kg | 25 mg/kg | 50 mg/kg | 100 mg/kg | 200 mg/kg | 400 mg/kg | |
| 1 | 26.4 ± 2.1 * | 17.5 ± 13.04 | 63.1 ± 12.1 * | 52.2 ± 6.1 * | 58.6 ± 6.4 * | 42.5 ± 11.1 * |
| 2 | 30.0 ± 4.5 * | 30.8 ± 8.24 | 55.7 ± 5.6 * | 70.1 ± 5.7 * | 36.9 ± 6.3 * | 41.7 ± 6.8 * |
| 3 | 63.1 ± 7.1 * | 40.5 ± 5.54 | 51.4 ± 5.5 * | 46.9 ± 5.8 * | 29.9 ± 4.6 | 33.1 ± 5.9 |
| 4 | 68.3 ± 8.1 * | 46.1 ± 4.05 * | 56.4 ± 4.2 * | 43.2 ± 2.7 | 24.9 ± 5.5 | 28.6 ± 5.0 |
| 5 | 67.6 ± 6.6 * | 60.1 ± 4.09 * | 64.5 ± 4.1 * | 45.2 ± 5.1 | 21.2 ± 4.9 | 19.9 ± 2.7 |
Results are expressed as percentage of inhibition and mean of eight determinations ± SE. ANOVA one way, Tuckey test * p < 0.05 for comparison of kramecine with indomethacin treated groups.