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Ascendant doses evaluation of HA in TPA-induced inflammation model.
| Substance | Time (h) | Dose (mg/ear) | Edema (mg) mean ± SEM | Edema inhibition (%) |
|---|---|---|---|---|
| TPA | 6 | --- | 9.8 ± 0.9 | --- |
| HA | 6 | 0.25 | 3.9 ± 0.6 * | 60.2 ± 6.5 |
| HA | 6 | 0.5 | 2.9 ± 0.7 * | 70.2 ± 7.4 |
| HA | 6 | 1.0 | 1.2 ± 0.4 * | 87.1 ± 4.4 |
| Indo | 6 | 1.0 | 1.3 ± 0.8 * | 86.0 ± 6.4 |
* p < 0.05 in comparison with TPA group; HA showed an E max = 97% of edema inhibition with an ED50 = 0.158 mg/ear.
