Table 1.
Entry | Isatin | Conditions a | Yield | Product |
---|---|---|---|---|
1 | 2 | 2.85 M, EtOH, 80 °C | 58% | 4E:4Z (23:1) b |
2 | 2 | 0.95 M, EtOH, 80 °C | 58% | 4E:4Z (1:20) b |
3 | 5 | 0.95 M, EtOH, 80 °C | 55% | 6Zc |
a reaction concentration, solvent, reaction temperature; b ratio of configuration isomers determined by 1H-NMR; c 6Z was the sole product observed in 1H-NMR.