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. 2012 Aug 24;17(9):10131–10141. doi: 10.3390/molecules170910131

Table 1.

Preparation of imines intermediates.

graphic file with name molecules-17-10131-i001.jpg

Entry Isatin Conditions a Yield Product
1 2 2.85 M, EtOH, 80 °C 58% 4E:4Z (23:1) b
2 2 0.95 M, EtOH, 80 °C 58% 4E:4Z (1:20) b
3 5 0.95 M, EtOH, 80 °C 55% 6Zc

a reaction concentration, solvent, reaction temperature; b ratio of configuration isomers determined by 1H-NMR; c 6Z was the sole product observed in 1H-NMR.