Table 1.
Cytotoxicity (IC50, μM) of compounds 1–8 against SNU-1 (stomach), HeLa (cervix), NCI-H23 (lung), Hep G2 (liver), K562 (leukemia), Raji (lymphoma), LS174T (colon), SK-MEL-28 (skin) and IMR-32 (neuroblastoma) cells.
| Compounds | IC50 (μM) * | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| SNU-1 | HeLa | NCI-H23 | Hep G2 | K562 | Raji | LS174T | SK-MEL-28 | IMR-32 | |
| 1 | 9.79 ± 0.23 | 9.20 ± 0.83 | 10.45 ± 0.58 | 20.64 ± 0.86 | 22.10 ± 0.61 | 11.67 ± 0.16 | 11.04 ± 1.08 | 11.04 ± 1.24 | 18.42 ± 1.06 |
| 2 | 1.98 ± 0.47 | 2.77 ± 0.59 | 2.64 ± 0.45 | 12.87 ± 1.03 | 2.23 ± 0.13 | 2.56 ± 0.80 | 3.17 ± 0.55 | 1.45 ± 1.04 | 0.69 ± 0.91 |
| 3 | 24.79 ± 0.78 | 6.88 ± 0.91 | 15.42 ± 0.83 | 6.22 ± 0.75 | 18.20 ± 0.76 | 15.50 ± 1.14 | 28.94 ± 0.57 | >100.00 | 18.60 ± 0.59 |
| 4 | 4.95 ± 0.85 | 6.95 ± 0.47 | 4.62 ± 0.38 | 11.12 ± 0.72 | 5.28 ± 0.22 | 4.44 ± 0.50 | 15.08 ± 0.94 | 39.64 ± 0.74 | 4.95 ± 1.20 |
| 5 | 20.66 ± 0.43 | >100.00 | 44.10 ± 1.19 | 24.81 ± 0.45 | 31.00 ± 0.21 | 26.16 ± 0.47 | 36.38 ± 0.37 | 28.92 ± 0.18 | 92.59 ± 1.00 |
| 6 | 15.71 ± 0.28 | 7.57 ± 0.44 | 82.67 ± 0.78 | 27.54 ± 1.48 | >100.00 | 20.66 ± 1.29 | 49.60 ± 0.71 | 26.85 ± 0.63 | >100.00 |
| 7 | >100.00 | >100.00 | >100.00 | >100.00 | >100.00 | 0.41 ± 0.87 | >100.00 | 9.47 ± 0.84 | >100.00 |
| 8 | >100.00 | >100.00 | >100.00 | >100.00 | >100.00 | >100.00 | >100.00 | >100.00 | >100.00 |
| Kaempferol ** | 38.22 ± 0.08 | 17.48 ± 1.13 | 65.56 ± 0.21 | >100.00 | >100.00 | 43.71 ± 0.80 | >100.00 | 76.15 ± 0.86 | >100.00 |
| Quercetin ** | 20.86 ± 1.01 | 26.49 ± 1.00 | 57.95 ± 0.31 | 17.25 ± 0.95 | 32.75 ± 1.20 | 6.89 ± 0.40 | >100.00 | 72.45 ± 0.84 | >100.00 |
* The data shown are means ± SEM of three independent experiments; ** Positive control.