Table 2.
IC50 values of isolated alkannin derivatives (1–8), acetylshikonin (9) and vinblastine (VBN) against different cancer cell lines. Mean ± SEM, n = 4.
| Compound | IC50 (µM) | |||
|---|---|---|---|---|
| CCRF-CEM | MDA-MB-231 | U251 | HCT 116 | |
| 1 | 2.31 ± 0.27 | 13.34 ± 1.35 | 15.01 ± 1.16 | 8.39 ± 1.20 |
| 2 | 1.67 ± 0.38 | 27.59 ± 8.25 | 41.70 ± 5.85 | 6.53 ± 0.87 |
| 3 | 0.98 ± 0.05 | 6.22 ± 0.46 | 19.17 ± 1.43 | 1.52 ± 0.05 |
| 4 | 0.53 ± 0.02 | 5.60 ± 0.36 | 16.39 ± 0.45 | 5.64 ± 0.14 |
| 5 | 3.32 ± 0.74 | 12.07 ± 0.13 | 69.70 ± 17.67 | 12.50 ± 1.05 |
| 6 | 0.39 ± 0.02 | 4.62 ± 0.14 | 3.17 ± 0.31 | 1.75 ± 0.06 |
| 7 | 1.22 ± 0.24 | 30.05 ± 5.92 | >100 µM | 7.97 ± 0.84 |
| 8 | 1.69 ± 0.15 | 12.21 ± 0.88 | 25.84 ± 0.66 | 6.83 ± 0.85 |
| 9 | 1.01 ± 0.09 | 11.33 ± 1.65 | 15.86 ± 0.67 | 9.02 ± 0.51 |
| VBN | 9.4 × 10−3 ± 2 × 10−4 | 3.1 × 10−2 ± 4.6 × 10−3 | 8.1 × 10−3 ± 1.0 × 10−3 | 8.7 × 10−3 ± 5.0 × 10−4 |