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. 2012 Nov 22;17(12):13712–13726. doi: 10.3390/molecules171213712

Figure 1.

Figure 1

Chronic treatment with 5′Cl5′d-(±)-ENBA reduces mechanical allodynia (A) and thermal hyperalgesia (B). SNI mice showed mechanical allodynia and thermal hyperalgesia only at the ipsilateral sides of the nerve injury at 3 and 7 days post-surgery. Administrations of 5′Cl5'd-(±)-ENBA (0.5 mg/kg), once per day, reduced reflex withdrawal responses to mechanical and noxious thermal stimuli in SNI mice and this effect was prevented by pre-treatment with DPCPX (3 mg/kg) (A, B). Data represent the mean of the mechanical paw withdrawal threshold and the thermal paw withdrawal latency for mechanical allodynia and thermal hyperalgesia respectively, of six randomly selected mice for each histogram. ° p < 0.05 vs. sham operated mice or naive mice, * p < 0.05 vs. SNI mice, # p < 0.05 vs. 5′Cl5'd-(±)-ENBA treated SNI mice.