Table 2.
Leishmanicidal and Cytotoxicity Activities of Piper demeraranum and P. duckei Essential Oils.
| Samples | L. amazonensis | L. guyanensis | Mice (Balb/c) macrophages | ||
|---|---|---|---|---|---|
| Promastigotes | Amastigotes | Promastigotes | |||
| IC50 ± SD | IC50 ± SD (µg/mL) | IC50 ± SD (µg/mL) | Cytotoxicity / (%) | ||
| P. demeraranum | 86.0 ± 2.4 µg/mL | 78 ± 1.0 | 22.7 ± 1.1 | IC50 7 × IC50 | 14.422.3 |
| P. duckei | 46.0 ± 1.3 µg/mL | 42.4 ± 0.8 | 15.2 ± 0.9 | IC50 7 × IC50 | 16.824.4 |
| Limonene | 278 ± 12 µM | - | - | - | - |
| trans -Caryophyllene | 96 ± 19 µM | - | - | - | - |
| Pentamidine | 4.6 ± 0.4 µg/mL | - | 0.8 ± 0.2 | - | 26.2 |