Table 2.
MIC values (μg/mL) of constituents from C. aurantifolia against M. tuberculosis.
| Compound | H37Rv a | H10 b | M15 c | M26 d |
|---|---|---|---|---|
| 5-Geranyloxypsoralen (1) | 50 | 200 | 100 | 100 |
| 5-Geranyloxy-7-methoxycoumarin (2) | 200 | 200 | 100 | 100 |
| 5,7-Dimethoxycoumarin (3) | >200 | NT | NT | NT |
| 5,8-Dimethoxypsoralen (5) | 25 | 25 | >50 | 50 |
| 4-Hexen-3-one | 50 | >200 | >200 | >200 |
| 3-Methyl-3-penten-2-one | >200 | NT | NT | NT |
| Resorcinol | >200 | NT | NT | NT |
| p-Cymene | >200 | NT | NT | NT |
| Linalool oxide | >200 | NT | NT | NT |
| Terpinen-4-ol | 200 | >200 | >200 | >200 |
| 3-Methyl-1,2-cyclopentanedione | >200 | NT | NT | NT |
| Carvone | 200 | >200 | >200 | >200 |
| Geraniol | 200 | >200 | >200 | >200 |
| Citral | 50 | >200 | >200 | 200 |
| Geranyl formate | >200 | NT | NT | NT |
| Oleic acid | 100 | 100 | 100 | 100 |
| Methyl palmitate | >200 | NT | NT | NT |
| Palmitic acid | 25 | 50 | 50 | 50 |
| Linoleic acid | 50 | 100 | 100 | 100 |
| Pinacol | >200 | NT | NT | NT |
| Ethambutol | 2.0 | 15 | 15 | 15 |
| Isoniazid | 0.02 | 5 | 7 | 6 |
| Rifampicin | 0.08 | 9 | 10 | 12 |
a M. tuberculosis H37Rv strain is sensitive to isoniazid, rifampicin, streptomycin and ethambutol; b,c,d M. tuberculosis H10, M15 and M26 are clinical strains resistant to isoniazid and rifampicin; NT: Not tested.