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. 2012 Sep 28;17(10):11616–11629. doi: 10.3390/molecules171011616

Table 2.

Cytotoxic activity of benzo[j]phenanthridine- and benzo[g]pyrimido[4,5-c]isoquinolinequinone derivatives.

IC50 ± SEM a (µM)
Compound N° MRC-5 b AGS c SK-MES-1 d J82 e
graphic file with name molecules-17-11616-i037.jpg 1 41.3 ± 2.2 19.0 ± 0.9 51.6 ± 2.7 62.6 ± 3.4
graphic file with name molecules-17-11616-i038.jpg 7a 35.4 ± 2.8 21.4 ± 1.3 >100 99.4 ± 6.6
graphic file with name molecules-17-11616-i039.jpg 7c >100 42.4 ± 2.3 >100 >100
graphic file with name molecules-17-11616-i040.jpg 7d 14.3 ± 1.2 40.5 ± 2.6 64.4 ± 3.2 59.7 ± 2.5
graphic file with name molecules-17-11616-i041.jpg 7e 32.3 ± 2.6 47.8 ± 2.5 >100 >100
graphic file with name molecules-17-11616-i042.jpg 7f 21.3 ± 1.1 10.1 ± 0.8 >100 >100
graphic file with name molecules-17-11616-i043.jpg 2 72.8 ± 3.4 82.1± 4.4 67.5 ± 3.6 78.6 ± 3.9
graphic file with name molecules-17-11616-i044.jpg 8a 30.3 ± 3.1 4.6 ± 0.2 12.4 ± 1.2 5.0 ± 0.3
graphic file with name molecules-17-11616-i045.jpg 8b 61.1 ± 5.4 36.1 ± 2.0 85.8 ± 5.1 >100
graphic file with name molecules-17-11616-i046.jpg 8c 31.8 ± 2.5 3.3 ± 0.2 >100 >100
graphic file with name molecules-17-11616-i047.jpg 8d >100 19.6 ± 1.4 >100 40.3 ± 3.3
graphic file with name molecules-17-11616-i048.jpg 8e 59.1 ± 4.6 18.5 ± 1.3 59.8 ± 4.5 23.4 ± 1.1
graphic file with name molecules-17-11616-i049.jpg 8f 77.8 ± 5.3 >100 74.1 ± 5.8 >100
etoposide - 3.9 ± 0.21 0.36 ± 0.15 2.8 ± 0.18 0.80 ± 0.04

a Data represent mean average values for six independent determinations; b Normal human lung fibroblasts cells; c Human gastric adenocarcinoma cell line; d Human lung cancer cell line; e Human bladder carcinoma cell line.