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Effect of ureas on topo II-α Line 1: Etoposide (100 μM) + pBR322; line 2: pBR322 only; line 3: pBR322 + topo II-α; line 4: pBR322 + topo II-α + 23 (10 μM); line 5: pBR322 + topo II-α + 24 (10 μM); line 6: pBR322 + topo II-α + 21 (10 μM); line 7: pBR322 + topo II-α + 22 (10 μM); line 8: pBR322 + topo II-α + 20 (10 μM); line 9: pBR322 + topo II-α + 25 (10 μM).
