Table 1.
Effects of trachylobane-360 isolated from Xylopia langsdorffiana on organ weights. Mice were inoculated with sarcoma 180 cells (25 × 106 cells/mL, s.c.). The animals were treated for seven consecutive days, starting one day after tumor implantation.
| Drug | Dose (mg/kg) | Thymus (mg/g body weight) | Spleen (mg/g body weight) | Liver (mg/g body weight) | Kidney (mg/g body weight) | Initial weight (g) | Final weight (g) |
|---|---|---|---|---|---|---|---|
| Healthy mice | |||||||
| (5% Tween-80) | - | 3.09 ± 0.30 | 5.21 ± 0.24 | 56.33 ± 0.49 | 12.23 ± 0.74 | 32.07 ± 0.79 | 32.38 ± 0.62 |
| Control-S180 | |||||||
| (5% Tween-80) | - | 4.36 ± 0.50 c | 6.85 ± 0.50 c | 63.30 ± 1.17 | 10.62 ± 0.13 | 31.43 ± 0.99 | 34.54 ± 0.90 |
| 5-FU | 25 | 2.13 ± 0.11 a | 5.24 ± 0.15 a | 57.52 ± 0.92 a | 10.67 ± 0.59 | 30.27 ± 0.49 | 30.35 ± 0.73 a |
| Trachylobane-360 | 12.5 | 3.80 ± 0.31 b | 7.62 ± 0.37 b,c | 63.04 ± 1.60 | 11.39 ± 0.28 | 32.10 ± 0.68 | 33.77 ± 0.70 |
| Trachylobane-360 | 25 | 3.41 ± 0.16 b | 7.59 ± 0.36 b,c | 58.75 ± 1.07 | 10.96 ± 0.56 | 29.73 ± 0.50 | 31.37 ± 0.53 a |
Data are presented as means ± SEM for six animals. a p < 0.05, compared to control-S180, by ANOVA followed by Tukey’s test; b p < 0.05, compared to mice transplanted with S180 tumor and treated with 5-FU, by ANOVA followed by Tukey’s test; c p < 0.05, compared to healthy mice, by ANOVA followed by Tukey’s test.