Table 2.
Effects of trachylobane-360 isolated from Xylopia langsdorffiana on biochemical parameters determined in peripheral blood. Mice were inoculated with sarcoma 180 cells (25 × 106 cells/mL, s.c.). The animals were treated for seven consecutive days, starting one day after tumor implantation.
| Drug | Dose (mg/kg) | AST (UI/L) | ALT (UI/L) | Urea (mg/dL) | Creatinine (mg/dL) |
|---|---|---|---|---|---|
| Healthy mice | |||||
| (5% Tween-80) | - | 217.6 ± 26.2 | 122.6 ± 19.1 | 41.2 ± 2.2 | 0.28 ± 0,02 |
| Control-S180 | |||||
| (5% Tween-80) | - | 287.8 ± 20.2 | 71.8 ± 7.3 | 39.8 ± 4.4 | 0.28 ± 0.02 |
| 5-FU | 25 | 219.7 ± 18.4 | 63.8 ± 9.7 | 48.0 ± 3.5 | 0.32 ± 0.02 |
| Trachylobane-360 | 12.5 | 275.0 ± 15.5 | 76.0 ± 10.4 | 48.8 ± 5.8 | 0.36 ± 0.06 |
| Trachylobane-360 | 25 | 298.3 ± 13.5 | 109.0 ± 10.1 | 51.2 ± 4.7 | 0.40 ± 0.04 |
Data are presented as means ± SEM of six animals.