Table 4.
Effects of trachylobane-360 isolated from Xylopia langsdorffiana on the hematological parameters on peripheral blood. Mice were inoculated with sarcoma 180 cells (25 × 106 cells/mL, s.c.). The animals were treated for seven consecutive days, starting one day after tumor implantation.
| Drug | Dose (mg/kg) | RBC (106 mm−3) | Hemoglobin (g/dL) | Hematocrit (%) |
|---|---|---|---|---|
| Healthy mice | ||||
| (5% Tween-80) | - | 9.87 ± 0.25 | 14.46 ± 0.27 | 42.94 ± 0.62 |
| Control-S180 | ||||
| (5% Tween-80) | - | 7.89 ± 0.36 c | 11.45 ± 0.73 c | 34.80 ± 2.35 |
| 5-FU | 25 | 8.60 ± 0.18 c | 12.95 ± 0.10 | 37.73 ± 0.93 |
| Trachylobane-360 | 12.5 | 8.79 ± 0.18 c | 13.03 ± 0.36 | 37.63 ± 1.10 |
| Trachylobane-360 | 25 | 9.67 ± 0.15 a,b | 14.28 ± 0.18 a | 40.55 ± 0.57 |
Data are presented as mean ± SEM of six animals. a p < 0.05 compared to control-S180, by ANOVA followed by Tukey’s test; b p < 0.05, compared to mice transplanted with S180 tumor and treated with 5-FU, by ANOVA followed by Tukey’s test; c p < 0.05, compared to healthy mice, by ANOVA followed by Tukey’s test.