Table 5.
Effects of trachylobane-360 isolated from Xylopia langsdorffiana on the hematological parameters on peripheral blood. Mice were inoculated with sarcoma 180 (25 × 106 cells/mL, s.c.). The animals were treated for seven consecutive days, starting one day after tumor implantation.
| Drug | Dose(mg/kg) | Total leukocytes (103 mm−3) | Differential count of leukocytes (%) | |||
|---|---|---|---|---|---|---|
| Lymphocytes | Neutrophils | Monocytes | Eosinophils | |||
| Healthy mice | ||||||
| (5% Tween-80) | - | 7.08 ± 0.51 | 77.80 ± 3.73 | 18.40 ± 3.25 | 3.40 ± 0.51 | 0.40 ± 0.24 |
| Control-S180 | ||||||
| (5% Tween-80) | - | 13.34 ± 2.58 c | 44.00 ± 2.54 c | 50.50 ± 3.16 c | 4.33 ± 0.56 | 0.67 ± 0.33 |
| 5-FU | 25 | 3.95 ± 0.51 a | 77.17 ± 2.18 a | 18.50 ± 2.32a | 3.50 ± 0.62 | 0.50 ± 0.34 |
| Trachylobane-360 | 12.5 | 11.15 ± 1.28 b | 51.83 ± 4.66 b,c | 41.17 ± 5.25 b,c | 6.00 ± 1.57 | 1.00 ± 0.45 |
| Trachylobane-360 | 25 | 11.42 ± 0.92 b | 53.17 ± 5.08 b,c | 38.67 ± 4.56 b,c | 6.83 ± 1.11 | 0.50 ± 0.22 |
Data are presented as mean ± SEM of six animals. a p < 0.05 compared to control-S180 by ANOVA followed by Tukey; b p < 0.05 compared to mice transplanted with tumor S180 and treated with 5-FU, by ANOVA followed by Tukey’s test; c p < 0.05 compared to healthy mice, by ANOVA followed by Tukey’s test.