Table 1.
Graded dietary salt intake induces osmotic dehydration and increases the stress hormone corticosterone.
| Salt Loading Treatment | Fluid Intake (mL/day) | Serum Osmolality (mOsm/kg) | Hematocrit (%) | Serum Protein (g/mL) | Serum Corticosterone (ng/mL) |
|---|---|---|---|---|---|
| Tap Water | 7.0 ± 0.5 (n = 6) |
330 ± 2.6 (n = 13) |
45 ± 0.6 (n = 13) |
5.5 ± 0.2 (n = 16) |
97 ± 16 (n = 5) |
| 2% Saline | 14 ± 1.9## (n = 10) |
333 ± 3.5## (n = 16) |
48 ± 1.1* (n = 11) |
6.2 ± 0.2 (n = 16) |
76 ± 12## (n = 5) |
| 4% Saline | 3.6 ± 0.6** (n = 11) |
388 ± 9.0** (n = 13) |
51 ± 2.0** (n = 4) |
6.6 ± 0.3** (n = 16) |
335 ± 78* (n = 6) |
Effects of graded dietary salt on fluid intake, hematologic measures and the stress hormone corticosterone. Values were obtained after the 7-day SL protocol. Water drank is the estimated daily volume consumed per mouse (mL/day). Data are mean ± SEM.
*
P < 0.01 significant difference from tap water controls;
**
P < 0.01 significant difference from tap water controls;
##
P < 0.01 significant difference from 4% saline treatment with Dunnett’s post hoc multiple comparisons test after a one-factor ANOVA. Values in parentheses are sample sizes.